Interaction between amyloid precursor protein and Nogo receptors regulates amyloid deposition
نویسندگان
چکیده
منابع مشابه
SORLA regulates processing of amyloid precursor protein via interaction
D i s s e r t a t i o n zur Erlangung des akademischen Grades des Doktors der Naturwissenschaften d o c t o r r e r u m n a t u r a l i u m Summary Alzheimer disease (AD) is the most common form of neurodegenerative diseases. Only little is known about the control mechanisms which affect APP metabolism and that cause Alzheimer´s Disease. Gene expression profiling studies revealed reduced levels...
متن کاملAmyloid precursor protein interacts with notch receptors.
The amyloid precursor protein (APP) must fulfill important roles based on its sequence conservation from fly to human. Although multiple functions for APP have been proposed, the best-known role for this protein is as the precursor of Abeta peptide, a neurotoxic 39-43-amino acid peptide crucial to the pathogenesis of Alzheimer's disease. To investigate additional roles for APP with an eye towar...
متن کاملAmyloid Precursor Protein
Intracellular trafficking and proteolytic processing of amyloid precursor protein (APP) have been the focus of numerous investigations over the past two decades. APP is the precursor to the amyloid -protein (A ), the 38–43-amino acid residue peptide that is at the heart of the amyloid cascade hypothesis of Alzheimer disease (AD). Tremendous progress has been made since the initial identificatio...
متن کاملamyloid precursor protein processing in alzheimer’s disease
how to cite this article: bhadbhade a, cheng dw. amyloid precursor protein processing in alzheimer’s disease. iranian journal of child neurology2012;6(1):1-5. alzheimer’s disease (ad) is a progressive neurodegenerative disorder and a leading cause of dementia. the ad is characterized by presence of intraneuronal tangles and extracellular plaques in the brain. the plaques are composed of dense a...
متن کاملLuteinizing Hormone, a Reproductive Regulator That Modulates the Processing of Amyloid- Precursor Protein and Amyloid- Deposition*
From Voyager Pharmaceutical Corporation, Raleigh, North Carolina 27615, the Centre for Aging and Alzheimer’s Disease, School of Biomedical and Sports Science, Edith Cowan University, Joondalup, Western Australia 6027, Australia, the Department of Psychiatry and Clinical Neurosciences, The University of Western Australia and The Sir James McCusker Alzheimer’s Disease Research Unit, Hollywood Pri...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2011
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fj.11-184325